Advances in Endocrine Therapies 2005
Novel treatments targets & therapeutic potential
19th and 20th January 2005 - Workshop 18th January 2005
Kensington Marriott Hotel, London

**** CONFERENCE BROCHURE AVAILABLE NOW - REQUEST YOURS TODAY ****

In such a wide reaching industry, it is important to focus on key areas of progression.  At this conference delegates will learn about new developments in significant areas of the market, from diabetes and obesity to cancer and hormone replacement therapies.

THEMES WILL INCLUDE:
**New developments in diabetes - how can your company enter this rapidly growing & changing market?
**Learn about new approaches to weight loss & emerging therapies for metabolic diseases
**Advice on how your company can become an industry leader in the market for infertility drugs
**Improve your clinical trials for osteoporosis & learn about the alternatives to HRT
**Achieve more efficient insulin delivery - optimise your potential success
**Benefit from the best practice case studies: Forteo; Passport; Somatostatin

KEY SPEAKERS
**Dr. Anthony Beardsworth, Lead Physician, Primary Care, Eli Lilly
**Dr. Monique Berwaer, Head, Metabolic Diseases, Johnson & Johnson
**Caroline Turnbull, Armidex Brand Leader, AstraZeneca
**Dr. Desmond Thompson, Senior Scientific Director, Merck
**Dr. Milan Zdravkovic, International Medical Officer, NovoNordisk
**Dr. Manfred Ganz, Director, Head of Medical Assessment Strategy and Business Development, Roche
**Dr. Bharat Tewarie, Executive Vice President, Reproductive Health, Serono
**Dr. Eric Tomlinson, Chief Executive Officer, Altea Therapeutics
**Dr. George Merriam, Scientific Advisor, Theratechnologies
**Dr. Gerald Bernstein, Vice President, Medical Affairs, Generex Biotechnology
**Dr. Alan Davis, European Medical Director, Kendle

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WHO SHOULD ATTEND
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**Vice President, Global Medical Endocrinology
**Senior Vice President, Endocrine Business
**Senior Medical Director, Endocrinology
**Director, Endocrinology & Metabolism
**Senior Director, Metabolic Diseases
**Global Head, Diabetes & Clinical Research
**Vice President, Diabetes
**Vice President, Glucose Monitoring Systems
**Vice President, Cardiovascular & Metabolism
**Executive Vice President, Women's Health
**Vice President, Reproductive Health

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This event will also feature: Pre-conference Interactive Workshop
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Glucose Sensing & Insulin Pumps
Workshop leaders: Ian Tilly, Glucose Sensor Specialist, Medtronic MiniMed Uk & Ireland
                        Susan Judge, Diabetes Specialist, Nurse & Education Co-ordinator.

Strategies for pricing and market access of innovative endocrine therapies
Led by: Christian Schuler, Director Health Sciences Division, Simon-Kucher & Partners


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DELEGATE REGISTRATION
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Places at this event are strictly limited so BOOK YOUR PLACE NOW.
To make a booking on this event, please contact me via phone or email. Book early to secure a place.

- PRICING -

Attend the:
2 Day conference with interactive workshop - ONLY GBP1600 plus VAT
2 Day conference - ONLY GBP1299 plus VAT
Workshop only - ONLY GBP650 plus VAT

- BOOKINGS -

Booking is easy, simply contact me:

Joe Stone      
Account Manager - Conference Division
Visiongain B2B Conferences
Tel. +44(0)20 8767 6711
Fax. +44(0)20 8767 5001
mailto:joe.stone@visiongain.com

B2B Conferences is part of the Visiongain Group


**** FULL CONFERENCE AGENDA BELOW ****

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PRE-CONFERENCE INTERACTIVE WORKSHOP
Tuesday 18th January 2005
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Glucose sensing & insulin pumps:
optimise diabetes care & analyse pump therapy

Led by: Ian Tilly, Glucose Sensor Specialist & Susan Judge,
Diabetes Specialist, Nurse & Education Co-ordinator,
Medronic MiniMed UK & Ireland

Main topics of discussion:
. Validation of new treatment efficacy in improving
  glycaemic control.
. Enhancing the value of clinical trials.
. Features and benefits of insulin pump therapy.
. Combining sensors & pumps - creating an artificial
  pancreas.

Strategies for pricing and market access of innovative endocrine therapies
Led by: Christian Schuler, Director Health Sciences Division, Simon-Kucher & Partners

Strategies for Pricing and Market Access of Innovative
Endocrine Therapies
. Challenges within the endocrine market environment
. P&R Environment for innovative endocrine therapies
. Key learnings from recent product launches
. The concept of value based pricing
. Pricing techniques

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Day One Wednesday 19th January 2005
===================================

09:00 Registration and coffee

09:30 Opening remarks from the chair

09:40 An Overview of the Industry
Dr. Ray Scraggs, Head Consultant at visiongain, will introduce
questionnaires which give you the chance to make comments
on the Endocrine Industry. The findings will be discussed at
the end of the day in a panel session.

NEW DEVELOPMENTS IN DIABETES

09:50 The Future of the Diabetes Market: What are the
Possibilities for Your Company?
. How to rise to the challenge for advanced and effective treatment
. Impaired metabolism: how to cope with complications
. Tactics for novel target discovery
. Strategies for genomics based drug discovery
. Tips on improving diabetes care - decrease complications and gain
  metabolic control
. How to avoid microvascular complications
. Different approaches to post infection therapies
Dr. Manfred Ganz, Director, Head of Medical Assessment Strategy and
Business Development Global Diabetes Care
Roche Diagnostics GmbH

10:30 CASE STUDY: 11 bHSD1 - A Novel Target in the treatment of
Diabetes & Metablic Symdrome
. The potential of selective 11 bHSD1 inhibition in the treatment of
  diabetes and associated complications
. The need for a better understanding of the endocrine function of
  adipose tissue
. Cortisol induced insulin resistance in man
. HSD1 and metabolic syndrome: what are the possibilities for your
  company?
. Effect of selective HSD1 inhibition in diabetic rodents: analysis of
  results
. The importance of 11beta-HSD1 in the development of metabolic
  syndrome - examination of data from studies of obese rodents
Dr. Monique Berwaer, Head, Metabolic Diseases
Johnson & Johnson

11:10 Morning Coffee

11:30 CASE STUDY: Incretin Mimetics - GLP-1 and Liraglutide
. Mechanism of action: increasing insulin secretion; reducing
  glucagon production; delaying gastric emptying
. What are the potential applications?
. Possible multiple benefits including weight loss vs drawbacks of
  delivery by injection
. Analysis of results of preclinical testing
. Potential for sustained action - improving patient care
Dr. Milan Zdravkovic, International Medical Officer
Novo Nordisk

12:10 Innovations in Insulin Delivery: Possibilities for New
Technologies
. What will be the future of the insulin pill? - replacing first phase
  insulin response
. Recent advances in insulin pump therapy - analysis of new
  possibilities & assessment of options
. The impact of oral insulin spray on the market
. Updates on FDA approval for inhaled insulin: overcoming long
  term effects
Dr. Gerald Bernstein, Vice President, Medical Affairs
Generex Biotechnology

12:50 Lunch

14:00 CASE STUDY: Passport - The Potential for Transdermal Insulin
Delivery
. Mechanism of action: a sonic applicator deploying
. ultrasound & introducing drug molecules through the skin
  Added benefits of combined skin patch and insulin pill
. Increasing administration length: new development of a 24 hour
  patch
. Advantages over alternatives - achieve steady and accurate
  delivery of your diabetes drugs
. Improve patient compliance - a non-invasive, pain and hassle free
  treatment
. Market potential - a cost-effective, efficient treatment without
  troublesome side-effects
Dr. Eric Tomlinson, Chief Executive Officer
Altea Therapeutics

NOVEL TREATMENTS IN THE OBESITY MARKET

14:40 New Approaches to Weight Loss Drugs: Responding to Gaps
in the Obesity Market
. Current drugs and their limitations: lessons to be learnt from the
  past
. How can body weight be regulated and modified?
. New approaches for discovering novel targets for the treatment of
  obesity
Jon Arch, Professorial Research Fellow, Deputy Director of Metabolic Research
University of Buckingham

15:20 Afternoon Tea

THE ENDOCRINE TREATMENT OF BREAST CANCER

15:40 CASE STUDY: Armidex - the Future of Treatment &
Prevention of Breast Cancer
. The first aromatase inhibitor to be approved - effect on your
  market
. Current market for breast cancer drugs - where can you capture a
  share?
. Developments in endocrine agents: steps towards the goal of
  breast cancer prevention
. Comparison of aromatase inhibitors with tamoxifen - how long
  before tamoxifen is obsolete?
. Analysis of results of recent clinical studies
Caroline Turnbull, Arimidex Brand Leader
AstraZeneca

16:20 Questions and Discussion

16:30 Summation of day one from conference chair

16:40 Close of Day One

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Day Two Thursday 20th January 2005
==================================

08:30 Registration and Coffee

09:00 Opening remarks from the Chair

DEVELOPMENTS IN GROWTH HORMONE THERAPIES

09:10 KEYNOTE SESSION

MINI SYMPOSIUM: GROWTH HORMONECLINICAL INSIGHTS & MECHANISMS
With invited manufacturers of growth hormone and growth
hormone secretagogues
Led By: Dr. George Merriam
Scientific Advisor, Professor of Medicine
Theratechnologies, University of Washington

10:10 CASE STUDY: Somatostatin - Developments in the Treatment
of Acromegaly
. Mechanism of action of somatostatin analogues
. The need to improve clinical management of patients
. Addressing patient issues: appropriate dosing regimes & extended
  duration preparations
. Defining the role of somatostatin analogues: checking & balancing
  hormones & growth
. Advantages of multiple benefits: treating adverse clinical effects
  of acromegaly
. SOM230: a new multiligand somatoststatin analogue - the
  possibilities for future treatments
Dr. Herbert Schmid, Senior Research Investigator for Somatostatin Research
Novartis

10:50 Morning Coffee

ENDOCRINOLOGY AND WOMEN'S HEALTH ISSUES

11:10 The Endocrinology Of Ageing
. Ageing - the major driver in the endocrine industry: gain your share
  of the market
. The underlying mechanisms responsible for reduction in strength,
  frequency and production of hormones
. Future targets for age-related diseases: what are the opportunities
  for your company?
Dr. Desmond Thompson, Senior Scientific Director
Merck

11:50 Delivering Clinical Trials for Osteoporosis: Improve your
Company's Studies
. Clinical trial metrics & management: ensure your osteoporosis trials
  are efficient & cost effective
. Tips for long & short term studies
. Advice on recruiting & retaining trial subjects
. How to select appropriate clinical endpoints for your osteoporosis
  trials
. Safety assessments & regulatory requirements: how do they affect
  your studies?
Dr. Alan Davies, European Medical Director
Kendle

12:30 Lunch

14:00 CASE STUDY: Forteo - The First Bone Formation Agent in the
Treatment of Osteoporosis
. Mechanism of action: the use of recombinant human parathyroid
  hormone: the potential to replace depleted bone stores
. Multiple benefits: forming new bone, increasing bone density
  and improving bone strength
. Overcoming possible side effects - what can be done to improve
  patient care?
. The proven success of Forteo: results from the fracture
  prevention trial
. Launch in India - tracking the success
Dr. Anthony Beardsworth, Lead Physician, Primary Care
Eli Lilly

14:40 CASE STUDY: Microencapsulated r-FSH - Novel Treatments
for Infertility
. The growing market for the treatment of infertility - tips for market
  share
. Learn from the experts - how Serono became market leaders for
  the treatment of infertility with Gonal-F
. Gonal-f(R) RFF Pen: the first and only prefilled and ready-to-use
  multi-dose FSH in the US
. Benefits of rFSH over urinary products - consistent potency & less
  contaminants
. Analysis and updates of recent clinical trials
. Future targets for the treatment of infertility
Dr. Bharat Tewarie, Executive Vice-President, Reproductive Health
Serono

15:20 Afternoon Tea

RECENT ADVANCES IN HYPERTENSION

16:00 CASE STUDY: SPP100 (Aliskiren) - A Novel Treatment for
Hypertension & Related Conditions
. A new mode of action for the treatment of hypertension & end
  organ damage
. Analysis of results of recent clinical trials & studies: Aliskiren Vs
  Irbesartan
. New technical achievements: producing a commercially viable
  manufacturing process
. Possibilites for multiple treatment benefits
Dr. Hans Brunner, Medical Advisor
Speedel

16:40 DISCUSSION: Attendees Perspective
Presentation and discussion of the questionnaire results led by Dr. Ray
Scraggs. This will involve some freeform discussion & the opportunity
to engage in knowledge sharing with fellow professionals.

17:00 Chairman summation and close of conference





Terms & Conditions
NB - Due to high demand, we do not 'reserve' or 'hold' places - a request for an invoice to be raised will be treated as an official booking and will be subject to the cancellation policy as outlined below.
Cancellations/substitutions and name changes: All bookings carry a 50% liability after the booking has been made, by post fax, email or web. There will be no refunds for cancellations received on or after one month before the start of the conference (e.g. cancellation on or after 20th January for a conference starting on 20th February). If you decide to cancel after this date the full invoice remains payable. Conference notes, which are available on the day, will be sent to you. Unfortunately we are not able to transfer places between conferences and executive briefings. However if you are unable to attend the event you may make a substitution/name change at any time as long as we are informed in writing by e-mail, fax or post. Name changes and substitutions must be from the same company and are not transferable between companies or countries.

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