Guarded Fragments: Current Trends and Applications (GF@25) April 5-6, 2022, Fully Online Webpage: https://events.illc.uva.nl/GF25/ The Guarded Fragment (GF) was introduced in 1996 by Hajnal Andreka, Johan van Benthem and Istvan Nemeti, as a decidable fragment of first-order logic that aims to explain the attractive algorithmic and model theoretic behavior of modal logic. It subsequently gave rise to a larger family of decidable guarded fragments of first-order logic and second-order logic. These guarded fragments are, up to today, still actively studied and used in various application domains across different areas of computer science and artificial intelligence (e.g., data management, knowledge representation). This workshop is a celebration of the 25th anniversary of GF. It will showcase recent results, bringing together different strands of research, and offering an opportunity for reflection. The workshop is fully online, with a program consisting of 7 invited lectures, spread out across two days.